University of Vermont Cancer Center Member Profile
Jeremy Logue, PhD
Associate Professor
Full Member
Cancer Host and Environment (CHE)
Academic Interests
Education:
Postdoctoral, National Institutes of Health
Ph.D., University of Washington
B.S., University of Oregon
Research:
The Logue Lab investigates the molecular mechanisms that govern cell migration, a fundamental process essential for development, immune function, and tissue repair. We focus on how cancer cells adapt their movement strategies within heterogeneous tissue environments, particularly the transition from mesenchymal to amoeboid (i.e., bleb-based) migration in response to confinement and low adhesion. This plasticity enables tumor cells to evade therapies and drive metastasis, which is the leading cause of cancer-related deaths.
Using engineered microenvironments, high-resolution microscopy, optogenetics, and fluorescent biosensors, our goal is to determine how various cell types, including immune cells, navigate different mechanical and chemical cues. By uncovering the biophysical and molecular basis of amoeboid migration, our goal is to inform the development of targeted therapies that disrupt metastatic spread.
Selected Publications:
Kar N, Caruso AP, Prokopiou N, Abrenica A, & Logue JS (2025). The activation of INF2 by Piezo1/Ca2+ is required for mesenchymal to amoeboid transition in confined environments. Current Biology (PMID: 40120583)
Link: https://www.sciencedirect.com/science/article/pii/S0960982225002805?via%3Dihub
Caruso AP & Logue JS (2024). The biophysics of cell motility through mechanochemically challenging environments. Current Opinion in Cell Biology (PMID: 39053178)
Link: https://www.sciencedirect.com/science/article/pii/S0955067424000838?via%3Dihub
Lavenus SB, Vosatka KW, Caruso AP, Ullo MF, Khan A, & Logue JS (2022). Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments. Journal of Cell Science (PMID: 35362531)
Link: https://journals.biologists.com/jcs/article/135/8/jcs259493/275197/Emerin-regulation-of-nuclear-stiffness-is-required
Ullo MF & Logue JS (2021). ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells. eLife (PMID:34169836)
Link: https://elifesciences.org/articles/67856
Education:
Postdoctoral, National Institutes of Health
Ph.D., University of Washington
B.S., University of Oregon
Research:
The Logue Lab investigates the molecular mechanisms that govern cell migration, a fundamental process essential for development, immune function, and tissue repair. We focus on how cancer cells adapt their movement strategies within heterogeneous tissue environments, particularly the transition from mesenchymal to amoeboid (i.e., bleb-based) migration in response to confinement and low adhesion. This plasticity enables tumor cells to evade therapies and drive metastasis, which is the leading cause of cancer-related deaths.
Using engineered microenvironments, high-resolution microscopy, optogenetics, and fluorescent biosensors, our goal is to determine how various cell types, including immune cells, navigate different mechanical and chemical cues. By uncovering the biophysical and molecular basis of amoeboid migration, our goal is to inform the development of targeted therapies that disrupt metastatic spread.
Selected Publications:
Kar N, Caruso AP, Prokopiou N, Abrenica A, & Logue JS (2025). The activation of INF2 by Piezo1/Ca2+ is required for mesenchymal to amoeboid transition in confined environments. Current Biology (PMID: 40120583)
Link: https://www.sciencedirect.com/science/article/pii/S0960982225002805?via%3Dihub
Caruso AP & Logue JS (2024). The biophysics of cell motility through mechanochemically challenging environments. Current Opinion in Cell Biology (PMID: 39053178)
Link: https://www.sciencedirect.com/science/article/pii/S0955067424000838?via%3Dihub
Lavenus SB, Vosatka KW, Caruso AP, Ullo MF, Khan A, & Logue JS (2022). Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments. Journal of Cell Science (PMID: 35362531)
Link: https://journals.biologists.com/jcs/article/135/8/jcs259493/275197/Emerin-regulation-of-nuclear-stiffness-is-required
Ullo MF & Logue JS (2021). ADF and cofilin-1 collaborate to promote cortical actin flow and the leader bleb-based migration of confined cells. eLife (PMID:34169836)
Link: https://elifesciences.org/articles/67856